Processing of Notch and amyloid precursor protein by -secretase is spatially distinct
نویسندگان
چکیده
منابع مشابه
Presenilins, Processing of β-Amyloid Precursor Protein, and Notch Signaling
specific functions. Notch itself is a single-pass transTwo seemingly unrelated avenues of research, Alzheimembrane receptor with large extracellular and intracelmer’s disease and developmental cell fate specification, lular domains (Figure 1A). During receptor maturation, have intersected at the presenilin and Notch genes. ReNotch is cleaved in its extracellular domain by furin or a cent report...
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*Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461; ‡Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520; §Aaron Diamond AIDS Research Center, Rockefeller University, New York, NY 10016; ¶Department of Pharmacology and Physiology, MCP Hahnemann University, 245 North 15th Stre...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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Cleavage of amyloid precursor protein (APP) by the Alzheimer's beta-secretase (BACE1) is a key step in generating amyloid beta-peptide, the main component of amyloid plaques. Here we report evidence that heparan sulfate (HS) interacts with beta-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP. We show that HS and heparin interact directly with BACE1 and inhibit in vitro proce...
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The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate additional roles for APP with an eye towar...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0408007101